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If a testosterone replacement regimen has the potential to boost muscle mass, its effectiveness and safety are key factors in determining whether to start. The research is preliminary, however, and the results have only been shown in a small number of healthy men, . "This preliminary study indicates the safety benefit is there; however, the magnitude of the effect are so rare and the adverse events so rare that it is hard to make a strong call on safety," said Dr. Michael Zee, a cardiologist and assistant professor of medicine at Stanford University in California. "I believe that even as more data comes in it will become more clear and that men need to be cautious if they are in the process of transitioning.

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